I was only going to bother with the sims who had a strong orientation in my game, but since my usual "Waiting for the mods to update" activity is to work on my save template (which has no CC) I've actually given them to several. For the most part, I've just decided if they're base interested in men or women (or both or neither) and left open to explore alone, but a few are getting more concrete preferences.
So far, Morgyn has ended up aro/ace, Don is straight as a pin, and everyone in Partihouse is open to whatever.