I have guilty drinker vampires and I don't really put too much thought into it when they eat food and never use the toilet. I play with all the occult weirdness, cowplants, became BFFs with Grim Reaper, I don't really care too much for realism or consistency, I keep my game silly and I don't care. :D
I have an immortal matriarch of my Legacy Save, and even as all her descendants grow old and generations pass, she's always there to lead the family. She's also married to Caleb Vatore and they have a lil' Vampire Clan club with Lilith and some other vamps I made. <3