When creating a family for multiple generations, do you play all of the descendants?

Yes! I start with a single sim, have them get married, start a family, then rotate with their kids when they move out. That way, the world never feels stale as each sim week, I'm playing a different household with different tasks, wants, and "feel." It's fun going between my normals, to my hippies, to my stangevillers, to my vamps, to my beach house, to my casters, etc... It's fun!