I use TS4 Mod Manager, which I think I got from Nexus, but I can't remember. It makes it really easy to turn specific CC on and off. I used to have folders for basically every type just as others do. You can specify folders in the Mod Manager, too, which makes it easy to locate. However, for several months I turned all CC off and only just got back into using it.. and I haven't organized any of it. It's a bit overwhelming, but I think most creators make it obvious in the CC name what the CC actually is, so that helps.