I had all kind of problems, including disappeared households, glitches, crashing, endless loading. I guessed it's because of scripts. Try to remove all the scripts from yours Mods folder. In the Mod folder bar *ts4script* and it will show what's installed. I removed everything, careers, Occult stabilizator, I left only MCCC and Tools. After removing my scripts my game worked. I recovered my saves from the point where was all my Sims characters. After that, some of them still was failed to load when I was testing for play. Then I installed this mode:
https://www.patreon.com/posts/mod-milestone-81237568
It works. You can also check my latest post here, scroll below to see what else I have done. Hopefully something helps. Good luck !