Can’t click on my Sims or do anything

@ragingredfox I know you did several of these steps, but can you please do these exact steps in this order to see if it helps by this method:

Please try the following:

• Exit your game then exit Origin. If you have mods or CC, please copy the Mods folder from your 'The Sims 4' folder to your desktop (for future reference) then delete the mods folder and the localthumbnailcache.package file in your 'The Sims 4' folder and restart the game and so that the game will re-create the folder.
• Then run a game repair [ Open Origin, click 'Game Library' then right-click Sims 4 > Repair Game ]. After that, please see if the issue has stopped. 
  (If It fixes the situation you can re-add your mods/cc one at a time to see if one was conflicting with the function/causing the glitch - but do not re-add the old config file from the old mods folder, as it is possible for it to have become corrupted also.)

Please let us know how it goes.

@ragingredfox Hmmm.... Interesting. Good detective work - and thank you for trying! In such cases it is good to do these steps first to make sure that the mods and cc and all of their potential effects are no longer part of the equation.

I actually had some buggy issues with that lot at one point, but I think in that instance I was overloading the lot a bit... and maybe pushing it's intended use with some of the things I was doing. (I made it a restaurant - a pretty involved one - plus had a large household who owned and ran it living there almost all of the time (though they had a home, as necessary.) Anyway, I had a number of buggy issues pop up then. If you would like to still have that lot for the family you could try starting a new, fresh save and uploading the penthouse from the new save into your library then downloading/overwriting the buggy one in that save you wanted to play it in, save it, then try moving your family in again and seeing if the issues have gone away.