@onebug7
If you've tried moving the Mods folder to the desktop, clearing the game cache and localthumbcache from the Sims 4 folder, plus repaired game.
It sounds like you've tried a test save without mods? Yes? And it's still giving you the error code?
Have you tried resetting your Sims 4 user folder?
You can reset your user folder by renaming it or moving it to the desktop and playing the game so it makes a new Sims 4 folder. Here's a how-to:
Resetting Sims 4 -
1. Click Start > Documents > Electronic Arts and look for the Sims 4 folder.
2. Rename the Sims 4 folder to Sims 4_Backup. The game will create a new folder next time you launch the game.
-- Renaming it or moving it to the desktop will help you have a backup and keep your Sims 4 files safe.
3. Repair the Sims 4 game. In Origin > Game Library - right-click on Sims 4 and select Repair. - To make sure the install files and such are in working order.
4. Try launching the game, play a new save. If it's not working, don't save. However, if everything is playing okay then start putting the files back. (list of files and folders below).
- Options.ini (User game settings)
- Tray Folder (Sims/Houses/Commercial lots and rooms)
- Screenshots/Videos/Custom music
- Rest of the save games, if any.
(leave out slot_00000001.save which is the autosave. It is not used anymore.)
- Custom content like clothing, hair, skins, and makeup
- Mods (Put these back one by one to make sure they all still work)
-- Notes on Mods and Custom Content --
Custom content can become outdated with most new game patches. If the game works when the Mods folder is removed, then one or more of the mods and/or custom content has become outdated and will need to be removed or replaced. EA/Maxis aren't responsible for broken mods/cc. It's up to the creators to fix.
Try the 50/50 method:
1. Move all the mods and cc out into a temporary folder on the desktop.
2. Move a few files back at a time. Load the game to make sure it loads and everything is good.
3. Delete the localthumbcache.package from the Sims 4 folder to help remove any traces of the mods or cc that were installed.
4. Repeat steps 1 - 3 till there is no more files to check.
** While your testing, don't save the game. If you find any problems, delete the mod or custom content file.
How To Find Problem Mods and CC -
http://simswiki.info/wiki.php?title=Game_Help:TS4_Finding_Problem_Custom_Content
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More information - Resetting the game to factory settings without reinstalling
https://answers.ea.com/t5/Technical-Issues-PC/READ-FIRST-Troubleshooting-your-Game/m-p/3621199#Resetting
If you move or rename the Sims 4 folder, the game will no longer be able to find it. When you go to play the game it will create a new folder.