My sims 4 game will not load after being left on all night. What do I do?

Post Edited by Author for Clarity on 5/2/2020

First of all rebooting after your PC Crashing while away likely won't do anything so your results are not unexpected with your thus far attempted remedies.

What I can say from what you've described is it sounds like you have an aging PC and/or Hardware situation; which you should be aware that these things cause faults in games that rely on higher-end computational requirements. To put it in plain english: Your PC might be in part or in whole dying, and the game is possibly no longer runnable by the reduced hardware specs.

Remedies if this is the actual case are not good news I'm afraid, there is a very good likelihood this will require at the very least specialized repairs if not a full PC Replacement (and on the topic of budget - i /fully/ recommend comparison shopping for a new PC over repairing the old one, it may just be (for example) the video card this time - but who knows what will break next). 

Other remedies you can try as a go between measure for hardware issues are reinstalling your operating system to attempt to "fix" missing sectors (specific to hard-drive failure), reinstall the game and/or restore backups.

In the future may I recommend not leaving your PC on overnight with performance intensive processes (such as graphical video games) running? I know in this modern world /everyone/ leaves their PC on overnight - but honestly just closing the stuff that's grinding away at the machine before bed will make a HUGE prevention act towards further damage. If your running on a laptop there are specialized sleep and hibernate modes that can also help, but even Desktops need to be put on a sort of "idle" to run 24/7.

In any case - I am assuming from the fact you said you preformed many necessary debugging steps that you have yourself already ruled out any other means of resolutions. You should always attempt to run debugging steps that are software related before hardware.

@oneshaylovely87  When you say you tried to move the game's program files, what exactly did you move?  If you haven't moved the user data folder out of Documents\Electronic Arts yet, please do so now, then try to launch the game.  Let me know whether it works.

If you didn't already clear Origin's cache (not the game but Origin), please do that as well.

https://help.ea.com/en-us/help/faq/clear-cache-to-fix-problems-with-your-games/

Restart your computer, and repair the game in Origin: open your game library, right-click on the Sims 4 icon, and select Repair.

And disable Origin in-game: hover over your username, select Application Settings, then the Origin in-game header, and disable the first option at the top.

If these steps don't help, please run a dxdiag and attach it to a post.

https://help.ea.com/en-us/help/pc/how-to-gather-dxdiag-information/

@LeissaMyst  It is not helpful to tell someone at this stage that their computer is "dying."  While hardware failure is a possibility, it is currently only one of many, and still somewhat less likely than other, more fixable issues.

I was going on the circumstances...I've had this happen personally, so I may be somewhat bias in the field of leaving your equipment running; but I don't consider it to be "bad" to consider that the user has followed the steps they have indicated and have encountered problems I'm familiar with. Also for clarification, the most important part of my statement was not that it was "Dying" but that it was /likely/ caused by the fact that the computer was left on for an extended period - which often causes hardware failure in machines as I've personally noticed. Hardware failure is 100% preventable in most cases, unfortunately once it occurs it's irreversible in many cases. 

My Apologies if I worded my advice poorly, but I don't think I was in error in my caution...