Re: Help please!! Sims 4 Not responding on startup

@meg9h  My previous comment about an antivirus blocking the game, or a virus corrupting your user accounts, applies here too.  It's not uncommon for either problem to be absent in a new account at first, then appear after you've run the game once or twice.

However, before you pursue that, the minimized game you show in your screenshot used to be caused by an overlay that interfered with Sims 4.  So try disabling any apps that come with overlays: Discord, Steam, etc.  Disable the EA App in-game overlay as well; the option is under Settings > Application.

Additionally, you can try forcing the game to open in windowed mode.  Go into Documents > Electronic Arts > The Sims 4, open Options.ini, search for fullscreen , and set it to 0 (zero).

If these steps don't help, we're back to antivirus/malware, and please read the relevant sections of the post I linked previously.

I do want to mention that someone else with this same issue solved it earlier today by reinstalling Sims 4.  But I don't know when their game last worked, and they never tested in a new Windows account, so I can't tell you whether their issue is the same as yours.