I have the same problem and i do in fact use custom content. Ive been thinking of manually trying to remove File by File to see which file is corrupting the rest. but i dont have that much time to waste im not exactly sure what to do and i hate having to completely restart my computer because it takes too long to reboot.
First try removing everything to determine if it's your cc or not.
If it is, the 50:50 method described here is the fastest to find the culprit: http://modthesims.info/wiki.php?title=Game_Help:Finding_Problem_Custom_Content
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