sims 4 not responding on loading screen

@SarahGames8  I don't see a dxdiag in this thread.  Never mind, I found the other thread you started.  Your dxdiag shows you're running the DirectX 9 version of Sims 4.  If there's no reason for that, please switch back to the DX11 version.  Please also let me know whether OneDrive is running on this computer—your C drive is small and doesn't have a lot of space, so I'm wondering whether OneDrive is messing with your user folder, trying to push files to cloud storage.

I would like to know whether you've moved the Documents directory, or perhaps only the Sims 4 user folder, to the larger HDD.  It's fine if you have; I just need to know.

Anyway, if the game works at first with no mods or custom content, and works with MCCC, then the problem is likely one of your other mods.  Some mods, including some adult ones, put files inside the saves folder too, which could be why simply removing the mods doesn't work.

Please try the 50/50 method, but with a new Sims 4 folder each time the game stops working.  You can put aside any mods that you confirm are fine, like MCCC for example, so you have a smaller pile to deal with.