TS4 won't work?

So, I fixed my first problem but, yesterday, Comodo {my anti-virus system} didn't regconize it. But, I was able to play it for a while. But now when I try to do what I did yesterday to play the game, it doesn't work. I'm not sure if it's because Origin and Comodo don't mix but I'm feeling like **bleep** for spending $60 on a game that ends up not working all because of my anti-virus system.