Re: Sims 4 Not responding

@rnyoung25  Please remove Reshade and try again to play.

If that doesn't help, please create a new admin Windows account and try playing in that.  Make it a local account, as in, don't link it with your Microsoft account, and don't sync with any other services you normally use either.  Don't create a symlink or do anything else to move the Documents folder or its contents; just try to play and let me know whether it works.

In your main account, did you move over the entire Documents folder or only the Sims 4 folder inside Documents?  I ask because moving all of Documents to an external drive is always a bad idea: Windows may run into serious issues if it tries to access Documents for any reason (and there are many reasons it would) while the external is unplugged.  It's fine to move the Documents folder to an internal drive, and it's fine to move the Sims 4 user folder to an external drive, just not all of Documents to the external.