If the audio sounds awful no matter the settings, try enabling Windows Sonic

I have an Astro A50 Gen 5 and no matter what settings I used in game the audio sounds awful, like you're in a tin can and the spatial positioning is whack. It doesn't matter if in windows settings I set NO spatial sound, DTS or Dolby outside of the game (I use DTS for most things usually because the spatial is so great).

For whatever reason though, setting it to Windows Sonic at least partially fixes it in game and it sounds 10x better.