@takitsu wrote:
FINALLY FOUND SOULUTION!!!!! I had the same problem as everyone else, boss would bug out of harpoons wouldn't die and crap (litteraly tried for 1 hour once -_-). but the low settings thing actually worked. change visuals setting to low, turn off v-sync, windowed (full screen), and resolution to 1024x768 60hz. rapidly pressing f for some reason has the opposite effect, so i recommend using your less dominant hand for button mashing.
This also worked for me with one tiny addition:
Mash the F button before the camera pans to the boss. Don't mash it wildly like I did originally, but slow and steady. When I mashed the button wildly, the camera would pan to the boss and pan out in a second or two and the boss would break free. However, if mashing the button while the camera is still behind Isaac's shoulder, it should work.
Also, we shouldn't be doing this. Visceral should fix the **bleep** game already...