Same issue. Starting at about the 8 hour mark I stopped being able to open the special armor chests with the three glowing orbs and I can no longer interact with the fen'harel or evanuris alters/statues. Then it fixed itself after the Siege of Weisshaupt. That lasted for one level and now I'm back to not being able to interact with the special armor chests or alters/statues or any timelost gateways. This is a pretty major bug and from what I've seen it's one that A LOT of people have. I know EA knows about it and yet neither patch has addressed it. It pretty disappointing to finish a huge battle and find a chest you can't unlock over and over again. It also is irritating the crap over the completionist in me. Other than that MAJOR issue I've no other performance problems. It's not my computer. It's your game. I'm waiting for the moment where this issue blocks me from progressing through the story completely. Edit: I'm starting second playthrough and just realized the wall behind the library table is supposed to have a bookcase with books. Mines been just a brick wall the entire time. I think the books disappear at the same time I lose the ability to open chests and statues etc. I'm trying to figure out the exact moment in the game this all happens.
Deleted entire game and all saves. Download game and doing a new, clean run after patch 2.
Edit 1: Lost all the books in the lighthouse bookcase behind the main table after Sea of Blood. Now there is just a brick wall. Have also lost the dagger on my hip. First sign of the bug.
Edit 2: Clean download and new game AFTER the second patch and I have the same problem, only this time it hit me faster. Sea of Blood was the 4th quest I did, and after I did completed it I couldn't interact with armor chests, fenharel or evenuris statues, or some (not all) of the timelost gateways anymore. I also lost all the library books and bookshelf behind the table in the library and Solas's blade from my hip. I've given up on a second run. I should get a partial refund for having SO MUCH content blocked for me.