@MACHINE_brHUE Please disable Kaspersky entirely, just long enough to test, and let me know whether it helps. Some antivirus programs have additional settings that need to be tweaked.
If you still can't launch ME1, please open this location:
[install path]\Mass Effect Legendary Edition\Game\ME1\BioGame
and move the Config folder to your desktop, then try to play.
If that doesn't help either, please try playing in a clean boot.
https://www.windowscentral.com/how-clean-boot-windows-10
When you reboot, go through the Task Manager's background processes list disabling everything that doesn't absolutely need to be running. For example, your graphics driver needs to be running, but MSI Afterburner and RGB control software do not. Disable Kaspersky as well for this test.
And if nothing makes a difference, please post a new dxdiag.