Did you tried to run Origin and Mass Effect 3 as Administrator?
Yes, I tried that. They both have run as admin permissions.
Do you use onedrive?
As for ME1 > ME2:
You have a folder named "ME1" under "Documents\BioWare\Mass Effect 2\Save" and the ME1 Save Games are in there?
If not, go to your ME2 "Save" folder (As said under "Documents\BioWare\Mass Effect 2" and create a folder with the name "ME1". (without the quotes) inside the "Save" folder
Then copy (not relocate) your ME1 save games into that folder. > Now ME2 should "see" your ME1 character.
Your user account is an Administrator account?
You only have one copy of the games installed? (For example, not an Origin and a Steam installation to the same time)
This sounds like a permissions or Registry problem.
Press the Windows key and "X" at the same time > Click on "Command prompt (Administrator)" or "PowerShell (Administrator)"
In the CMD or PowerShell window, at the prompt type or copy: takeown /F "xxxxxxxxxxxx" (With the quotes. Replace the X with the full path to the ME2 folder, C:\Users\>your user name<\Documents\Bioware\Mass Effect2) > hit "ENTER"
If this don't works, create a new Windows user account > reboot > log in to the new account > test.
