Mass Effect 3, origin does not work in-game, can't invite friends or view downloadable content in-game.

When I open Mass Effect 3 origin doens't do the usual pop-up, I can't use **bleep**f+F1 to open up origin, and thanks to this I can't view downloadable content or host and invite friends. Any solution you guys can offer? I've uninstalled and installed origin various times, I do have "Enable Origin In Game" checked, but for some reason I can't use origin inside game. Especially annoying since I want to play with friends and not randoms at times.