Mass Effect Legendary edition already running?

@Masseffectgods 

Did you restarted your PC? A real "Restart", not just shut down and start again?

Please create a DxDiag in text file format and post it with your next reply. You can do that with the "Choose file" button at the bottom right corner of the reply window. 

Hi, and thanks for responding. Yes I've done full restarts.

I've attached the DXdiag files. 

@Masseffectgods 

It looks like your Monitor is connected to the wrong GPU port.

Please connect your Monitor directly to your 4090:

while that didn't fix the problem that did a lot to fixing a huge mess I had with graphics glitches... that was a bit embarrassing lol. Ty for that.

@Masseffectgods 

You're welcome!

Please post a new DxDiag as the configuration has changed significantly.

new Dxdiag

@Masseffectgods 

If you restart the PC and start MELE you probably don't get the "already running" message, do you get any other Error message?
Do you have the game on Steam or on EA app?
Do you have the newest ASUS Chipset and system drivers installed for your motherboard? 

There is a error message related to the NVIDIA graphic driver in your DxDiag.

• Follow this manual to the letter to cleanly uninstall all NVIDIA components.
• Install the graphics driver and GFE (Or NVIDIA App) > Go online.
• Test.

Ok, I've followed every step that you've given me so far. It still hasn't solved the problem of saying the game is already running. However, you did fix a number of issues that I was having so thank

you so much for that!

@Masseffectgods 

Well, that is at least some progress. 😉

• Press the Windows key and "R" at the same time
• Into the new window, type or copy & paste:  "%temp%"   (Without the quotes.) > hit "ENTER"
• Now your Windows Explorer should have brought you to the "C:\Users\>your user name<\AppData\Local\Temp" folder. > Delete all files and folders in it.
  (If some files or folders can't be deleted, reboot and try again.)

Then:

• Go here and download "Revo Uninstaller". (The freeware version, Portable version works too.)
• Run "Revo Uninstaller" > Uninstall EA app.
• At the end of the main uninstall, Revo will ask you which cleaning method you want to use. > Select "Intensive" > Browse
• If "Remaining registration content found" is displayed > Select All > Delete > Next
• When "Remaining Data and Folders" is displayed > Select All (Make sure the "Origin Games" or "EA Games" folder is not in the list!) > Delete.
• Restart the PC > Reinstall the newest version of EA app from here.
• Repair the game
  (Origin: Game Library > Right-click the game cover > Repair)

  (EA app: My Collection > Click on the three dots on the game cover > Repair)
  (Steam: Game Library > Right-click the game > Properties > Local Files > Verify integrity of game files.)

• Test

Did everything and still getting the same message. here is the new dxiag