Forum Discussion
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Did you applied the changes in the in game menu?
Do you use manufacturer software like Logitech Gaming software for your mouse?
Also disable Steam or Origin overlay for ME1.
that I have and the keyboard and mouse is a combo pack that I bought from a store over a few years ago from Logitech and i'm running windows 10 and gone download the gaming software is out of the question since it's not really compatable at all with the newer os.. As far as steam and the other platform it's totally disabled
Please try to repair the game. (in Origin > my games > right click ME2 > Repair Game) (in steam > right click at ME2 > Properties > Local Files > Verify integrity of game cache.)
On what client did you buy ME1?