Changing the video output setting to windowed borderless works for me.
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That mouse cursor bug is often happenign to me when tabbing and multitasking to other windows. When I come back to ME:A full screen the cursor is there stuck in the middle.
For me I have a rather easy solution: just open Origin overlay in-game and close it again (default is SHIFT+F1 and then ESC). And everything is fine again.
Hope it helps others.
