Things I'd like to see:
Next Patch
1-quick save/quick load keys
2-some type of save option in those critical missions where the save is disabled. I know this has existed since ME1, but if you won't give us some type of save option, at least give us an "Exit Save" (if we're in a safe/stable location) so that we can come back to the game where we left off if we can't complete it in one session ("What? I know the kids are hungry, hun, but I can't quit the game yet because I'll loose part of my progress.")
3-ability to upgrade my companions weapons/armor. I know this may be related to combat balance and may never happen, but I really miss being able to upgrade them.
4-having my companions walk around with me on the Nexus so that they will jump into conversations, comment on different things, or the 3 of us just stop to talk when we see something interesting. Right now it's just kind of lonely.
5-a key for auto equip or remove the helmet. We can draw or holster our weapon, why can't we take off our helmet or put it on with a key stroke? Hey, if you take off your helmet in a hazardous environment, you die. Period. No problem. But my character really feels kind of backward as the only one walking around in a safe environment with his helmet on. Unless he decides to talk.
Those are my current top 5 requests.
1st Single Player DLC
We can only have so many logical tie-ins to ME1-ME3, but I would like to see something with the Quarians.