You could try Resetting Catalyst Control Ceneter (CCC) 3D Properties to Default.
It definitly seems like a GPU related issue.. you might see if Realtek has newer drivers for the sound.
For GPU I'd try uninstalling the drivers completely, restarting into Safe Mode, run Display Driver Uninstaller, restart, install latest Betas or Stable.
http://www.guru3d.com/files-details/display-driver-uninstaller-download.html
If the card is one of those double GPUs on one board.. you could try disabling Crossfire. If you can't seem to do it through CCC if you set the game to Windowed Bordleress I do not believe Crossfire will be active... might be wrong...
RadeonPro can probably disable Crossfire.. but not sure.
