I can run him as fast as 235, but i have chosen large potency secondaries in lieu of speed. Mine runs at 215 speed. You certainly want his calous conviction zeta'd. It will give up to 100% potency, alone, when you use intimidation tactics. This doesn't even figure in his base potency, mod potency or currently stacked potency bumps. This all can lead to massive aoe hits and also to outlandish defense numbers.
I have not encountered a scenerio where he takes zero damage due to high defense, but i have seen him take under 100 damage points before.