Rank the aspirations!

Pleasure
- I love this simply for the ability to write restaurant guides (that I often headcanon as cookbooks). Even better this unlocks at tier 3 already, so Pleasure can get tacked on as secondary aspiration easily.
- Pleasure sims love dates and I also love dates for their ability to completely bypass the wants system - one dream date and you're set for some time, so a paired Pleasure sim is extremely easy care.
- DON'T fulfill their small wants like changing into sleepwear, this will only train them to roll more of them. (I didn't know that for years, but Sims 2 sims apparently are more likely to roll wants you have completed before)

Romance
- The better family sims in my opinion. They can learn to roll generic Woohoo wants instead of Woohoo with x sims, and woohoo being high point wants, these will last them for a while.
- I just wish romantic relationships gained at college would clear upon graduating just like they do for teens. My college sims are pretty active in this regard, what can lead to way too much drama in their early adult years.

Knowledge
- Although I like this one thematically, and even make some athletes Knowledge sims, reasoning this aspiration can also mean that they generally want to excel, I'm not good at the mechanics. The later skillpoint wants are hard to fulfill if not cheesed with eggplant juice or the simvac, and the occult wants sometimes don't fit my setting.

Fortune
- The probably cutest thing in the aspiration system is two fortune sims dating and then wanting to buy expensive paintings instead of woohooing as their date's peak.
- Their rather big downside is that their skill wants for the next promotion tend to clutter their want panel. Try taking a fortune sim on a vacation and they won't get their minds off their work skills in three slots (and the fourth will throw some pesky hobby want, most likely).
- Edit: Even worse, I just remembered that these skill wants are "Get a point in skill x" wants. "Get a point in skill x" gives a much smaller reward than "Reach skill level x". So if you yearn for your 8th skillpoint, please have the decency to also wish for "Skill level 8" (the way Knowledge sims do)!

Family
- Unpaired family sims are a hassle, they always want to flirt with everyone they see. And after getting paired they want to turn into baby factories.
- The only upside here is that they don't care much about careers as long as they can support their families. They roll career related normal wants, but rarely LTW's, so I'm free to put them into whatever I imagine they'd really want to do, not what the game thinks they want.

Popularity
- Relationship management is tedious. End of story.
- (Like many posters before me I'm not very social in real life either, funny thing is, except for swimming I dislike sports irl, but absolutely enjoy playing with athletic/sporty sims.)

Grilled Cheese
- I like watching my sims eat and downloaded a variety of custom foods, so this one is really boring for me. I also dislike the memories getting cluttered with Ate Grilled Cheese ones.

I make Fortune sims the most, because rags to riches is my main style of play. Knowledge sims come second. I tend to not get around to playing the others much; I keep going back to the ones I like most.

Oh this seems fun!

Family is probably be my favorite. I love playing a household where it's just this wholesome couple raising their kids (and getting the want to have another baby days after giving birth LOL).

Knowledge is my second favorite. Having career-oriented sims that want to work on their skills are always fun! They get cool wants that tend to spice up the gameplay.

Fortune: I prefer Knowledge sims but Fortune isn't too far behind for similar reasons. These sims are career-oriented and usually want to better themselves and their house.

Popularity & Pleasure: I'm putting these two together because I don't prefer one over the other. It's nice sometimes to have a sim that constantly wants to make friends and go places. It spices up the gameplay and usually leads to drama.

Romance: I feel bad putting this one at next to last because I do enjoy my romance sims quite a bit! I just prefer family gameplay and sims that actually have wants other than woohooing around with everyone.

Grilled Cheese: I've never actually played with this one.

My favorite aspiration would be popularity. I feel this aspiration gives the sim more out of their life they are popular and most sims want to hang out with them. You have a wide variety of things you want to do.