Sims 2 Collection unable to click to tell sims what to do

Hey Chellan93​ , what type of mouse are you using? Is it a "regular" mouse or a mouse that requires driver updates?

Have you also tried launching the game in Windowed mode to see if that helps? From EA app click on The Sims 2 > Manage > View properties > Add the following characters to the "Advanced launch options": -w