One time, the game turned against me. I kid you not.
I had an heiress I had been playing for almost two years. I liked her so much that I even had her take the age-freeze potion to stop aging in the middle adulthood span. Clearly my game wanted her dead. Whenever I lit the fireplace, house fires broke out and she always died. Most times I had just saved, so I would just quit the game without saving and restart. When I decided to get rid of the fireplaces. She as abducted by aliens, electrocuted, and struck by lightning. I even had to have a family member resurrect her after she died suddenly.
Eventually I got tired of fighting death and began playing someone else. But it was infinitely annoying!