I am still unable to run The Sims 3 in Windows 10. I tried what tech support told me - downloaded new drivers from NVIDIA and set up a profile in the NVIDIA GeForce Experience utility. Uninstalled and reinstalled The Sims 3. Removed my saves too even. Tried compatibility mode, and Windows 10 ran its compatibility mode thing and found the launcher file to be incompatible.
Did you try right clicking on the ts3 file and selecting troubleshoot compatibility and try the windows 8 mode? to get to said file right click on sims 3 icon, choose open folder location and scroll down to ts3 file. You probably know that but just in case you don't or someone else does not that reads this. Good luck.
