@kittell17
@holger1405 I'm doing this so the game can run faster. The link that EuphorialQueen provided explains that.
No, the link explains exactly the opposite.
You asked what files you can "safely delete after each game play".
Crins guide explains that the cached files need to be created if they are not present.
And creating them will take longer than loading them from the cache already existing on your hard drive.
So deleting the cache after each game session will increase your loading times and it will not at all speed up the game, not to mention that you might botcher your installation if you make a mistake.
Plus, it will not make any difference to the amount of space used on your hard drive, because, as said, the files get created again anyway.
It can be helpful to clean the cache after several months of playing, but it makes no sense whatsoever to do it after every game session.