I play with full autonomy on when I only have one sim to controll, without autonomy it gets boring for me.
The only issue I have is that sometimes it can be a bit too much, like if my sim has a knitting box in her inventory she will cancel whatever she is doing to start knitting. Same now with the vacuum. My sim can be starving and in the middle of food prep she pulls out the vacuum and starts vacuuming her perfectly sparkling clean home and get an uncomfortable moodlet cause of hunger. Like tune it down a bit, thanks.