I play with autonomy on always. I like it because I like to see what sims do on their own while I play on another. It also lets me see what kind of sim they really are sometimes. If my sim starts randomly flirting with another, I might start a fling with that sim. I like to storytell also so it helps with the story too, especially to have some drama. I never played with autonomy off, I always wanted my sims to act on their own when it comes to certain things and work whatever story I can around that. Plus it also makes it more intersting to me.