I'm kind of in the "Other" category here. I have autonomy on but I direct more of their actions and cancel a lot of autonomous actions.
Autonomy is really just on in case I decide to go with letting them do whatever action popped up. Usually, I queue up a series of actions for each sim and adjust as I go.
All of my sims are actually different, I do have concepts of personalities for them and I basically manage their lives. I'm not a control freak, I'm more like a director.
When coming up with what they want to do, I think about that specific sim and a concept of personality forms. Sometimes I might just decide to fill up their needs or I'll look for ideas based on the time of day or professional needs. Generally, I come up with interests and personalities through play. It's actually somewhat complex or subtle. I guess I think about what is motivating a given sim at any particular time.
That could just be grabbing random leftovers from the fridge or deciding it's a rainy day to do laundry. It could be someone deciding to go on an adventure or master a specific skill. I don't know, it works for me and I don't want to change. I find it easy to manage all of the sims.
I have households of various sizes including some with up to 8 sims. There's generally a lot going on then. I sometimes pause action while lining up activities for different sims.
I realize that I wrote this in a hurry while multi-tasking a lot so I edited it for clarity.