While I still worry about people who are differently abled being misrepresented or upset because their personal abilities are not represented at all, I think the idea of having supernaturals with the ability to have a different skill set might be intriguing to people in general.
I know he's not a supernatural so much as a super hero, but look at Daredevil. He's a blind man who uses sonar to find his way and help others. Maybe that goes a step too far, I don't know. I think my daughter, who has a developmental disorder similar to Asperger's, would love being able to create a werewolf, vampire, witch, etc... with similar abilities to herself. For me, being deaf (or mostly so in my case) the idea that my vampires might have to rely on scent, or sight to eat is somewhat intriguing.
Regardless of what gets implemented, I hope its done respectfully, tactfully, and with the real people behind the keyboards in mind.