I think with careful planning, it might be able to work. For mental disabilities anyway. The problem with disabilities in the sims 4 would be how the traits already feel like they don't affect gameplay. A few sad moodlets here and there wouldn't be an accurate representation of severe depression. A couple of dazed moodlets couldn't even begin to describe how people with schizophrenia feel. If they were to add disabilities, they would have to make it big, game changing, life changing, the way it is in reality. Because a couple of sad moodlets doesn't equate to the soul-crushing, never ending sea of grey that destroys all want, interests, and feelings the way depression does in real life. So I say it's difficult, but possible if enough effort is put into it.
