Disability feature: The Why’s & Why Not’s, and if so, How?

Just by reading this thread I don't see how this can possibly be implemented without it becoming a mine field of disastrous consequences. There are so many types of disability, both visible and not visible with so many varying degrees, I just don't know how a video game manages to implement it without some people feeling unrepresented, and some feeling mocked even. Speaking as someone with disabilities as the result of cancer treatments, I just think it's better not to go there.