I can understand wanting to see someone like yourself in general, but including the dark and painful aspects just wouldn't add any benefit to the fun of the game, so I think that level of it would be more of a drawback than a benefit.
In real life, it might take 30 minutes just to walk across the room to the bathroom for a person who can't afford a wheelchair but still has to go the bathroom. Once they get to the bathroom, they are in too much pain to deal with their own clothing, and have to have someone help them. On days when the pain is too great, they can't make themselves food or get themselves something to drink because they can't even get out of bed. Because typing can be too painful for some, they have to use the onscreen keyboard, or go without communicating or using the computer until they get lucky and feel better enough that they can. Which sometimes can be forever.
There are a lot of things like this that would just add no benefit to being played out in a game, have no entertainment value whatsoever, and yes, they could make the game feel like a sad and depressing place to be if we were to start seeing it everywhere like with the sick pets.
I'm all for basic things like wheelchairs and motor chairs and general things of that nature. Basic aids for blind people, and things like that. But I think that going beyond a general surface might be a mistake, could never please everybody, and could end up taking things in the wrong direction because they took it too far and it backfired. Things like that should be left up to the individual to work into their gameplay using the already available game structures, because there's no way to emulate every tiny thing, and close enough in general is as good as they could realistically do with it.
