Only about 3 in my game so far, but of those I only actively played one.
Tracy Scott was a MtF sim I created right after noticing we could do that to marry one of my legacy spares. Thy had a daughter, and I've kept that family line going because I liked the daughter's genetics.
Another, Stephen Downey, was created for the Hawthorne Project Sims but with that apparently over, I might try to find a place for him in one of my saves.
https://i.imgur.com/bSGxwCi.png
Masami Sasaki was actually the second created, and the only one played from young adult to elder. https://i.imgur.com/GukKcOW.png?2
https://i.imgur.com/GlncOxe.png?1