CC. Skins and overlays are to be avoided, period. They have been nothing but a hassle to deal with. Between getting broken, and the fact that I've had a ton of weird problems with it (i.e. Sims entirely missing their face, tongues and teeth that are floating in front of the head). I have (from places other than the gallery) downloaded Sims that originally used skins and overlays, just adding their Tray files and not the CC; and have been quite surprised at how good some look even without all that extra stuff. Of course, almost all of them are bald and wearing nothing, so you've got to start over with what the game has, not the CC used by the creator.
Mods. No mods that allow a Sim to do something I wouldn't. And yes, there are some weird mods out there. I honestly have no problem with the infamous, but widely used here mod that we can't mention by name, but there are some that involve some really sick, graphic stuff.
Actual gameplay. Unless my Sim knows another Sim well, I do not even bother to respond to their invitations.