Do you switch off Sim Culling?

I play rotational and am really kinda confused and worried about sim culling ever since I first found out that existed. I was curious to know if it's okay to stop it happening with MC command center or if that's something that is going to be bad for my game. I do have a fairly good computer that runs the game on ultra settings. I just really don't want to loose sims from my families or that my sims might have befriended. I've already disabled relationship culling but I still feel worried about population culling.

Sorry in advance if this thread breaks any rules or is posted in the wrong place.