When I do, I only use CAS and Build/Buy mods. I never use gameplay mods because those are the ones that are much more likely to break the game... also, in my opinion, I don't think modders should be the ones doing the developers' jobs. It's truly sad how modders are often creating better features and content than the actual developers do... and they do it for FREE!
I shouldn't have to play with mods to make the game interesting... because the developers should be doing that!