I enjoy playing rotation style too, although a bit different. I enjoy seeing how a neighborhood might change over time.
In my current save, I've played San Myshuno. I've moved some people in from other neighborhoods, played out a romantic story for others, developed them in their careers, brought Darling's mother in to shake things up, etc. Essentially, it's now the city as it might be a year or two into the future.
I'm currently working on Willow Creek. So far I've played mostly with the Goths and Pancakes as far as developing their families, although I try to weave the rest of the world into the story as I can. I'm now on the Spencer-Kim-Lewis family. I also update lots and houses in the neighborhood as I go.
The Goths and the Pancakes are actually brought over from my old save which got corrupted. I copied and pasted the new versions of the Goths onto their old forms, except for Alexander. The idea being that he has manipulated his family into a new timeline to prevent Bella's abduction, but he remains the same. He also has a new little brother, Sebastian.
The Pancakes have Iggy and an alien daughter of Bob's, Chloe. Mostly they've achieved happiness by encouraging Eliza to get a job, take up painting as a hobby, and basically work on her dreams herself. Bob is primarily responsible for the children and makes money with his baking. This means the house is messier and noiser than Eliza prefers, but she has her own spaces to retreat to, and she loves her children. Yes, she does consider Chloe hers.
I do need to take breaks from the game. I've been away from it for several months, but now I'm ready to play again. This way I get to start with my old save, but focus on a new family in the neighborhood. I've started by expanding the Spencer-Kim-Lewis family. Vivian has two daughters, one who lives elsewhere in the neighborhood on her own and one lives with her. Dennis also has a teenage daughter who lives in the household and shares a room with Vivian's daughter. I didn't plan on it, but last time I played Eric got abducted by aliens and is expecting. I paused the pregnancy since I also have him finishing college courses at home. But I think soon, he and Bob are going to have to get together.