I don't run all night on the sims, not for this game, but could better if you development your sims with all bunch of traits reward, then good chance they would be fine and not even lost job, if you got most of all reward store traits, that is, but sims with no traits/no development would likely in bad ending while sims with very development/vampire would had good ending if left all night, (depend on if aging off or on (if age is on, then vampire are kind of best path to left alone, after you done development right perk in vampire tree)
Very rare I left game run all night, but this game Sims 4 isn't design for running night, but on other hand, if we talk about X4 Foundations or X3 Terran Conflict or X3 Albion Prelude, then that game is make sense to run all night to make you credit to buy spaceship or spacestation, but this game sims 4, it's don't make sense to run all night, but I guess it's would be funny to see what would happen for one time, but everyday? No.
