I'm very random and unorganized when it comes to who I play and when. I have one main heir each generation but will check in on relatives now and then and make sure things are running smoothly (or not so smooth, depending on my storylines).
I started my save file with two sims, one founder and the guy she ultimately married. I didn't play with the guy until he moved into my female sim's household so there was no rotational playing going on at the time.
Fast forward an entire generation and I now have three adult kids for generation two, as well as my heir's future wife's family (that I've played with a bit to give them some jobs and relationships). I have a specific heir that I'll be focusing on, but I also really love the two other kids and will likely play with their households once their respective families start growing. At the moment the eldest is married and pregnant. She'll be having the first gen 3 babies.
I played with her household for major events like her wedding day and to get her pregnant. I also went in and out of her household a few times over the next couple days to get some baby bump pictures. My sim pregnancies last six days instead of three so I'm not feeling too rushed when I'm in other households. That's definitely an important part for me- having longer lifespans and longer pregnancies so I can do more and not feel like people are going to age up on me. Having MCCC is good for controlling sims in the meantime too, and making sure they won't have surprise birthdays. (I have paused aging altogether at some points when I wanted to do some storytelling and not have everyone grow up too quickly. You can do that if you're feeling stressed out!).
My heir is the middle child and he lives with his brother at the moment in an apartment in San Myshuno. They'll eventually go their separate ways when they get together with significant others, but for now I get to develop both of them.
I'm sure when I start getting gen 3 kids and they start growing up, it'll be A LOT harder to rotate between all of them. I might have to choose a few favorites to focus on and let MCCC do the rest of the story progression for me. I don't think I can handle 20+ active households LOL.
One day when I get bored of this save file (hopefully not for a VERY long time!), I want to make Newcrest into a "soap opera" type town where I play with 9-10 families at once. If I do end up doing that, I'll probably play one sim week in each household and have a specific schedule so everyone will get equal play time. I haven't done it, it might end up feeling too strict for my taste, but it's something I'd like to at least try.