I have never had any problems using the potion to remove Quirks. As another player suggested, try repair game. If that doesn't work, go for a refresh on your gaming folder. Make sure you back-up your current one, so that your Tray and saves are intact. Do this FIRST. Then remove the folder from your documents>Electronic Arts> Sims 4. Start the game again. The folder will regenerate.
Then you can change out the empty Tray for your old Tray, and likewise, the saves for the old saves with your games intact. Then see if you're having the same problem. All this is done when the game is OFF.
Hope this helps. Happy Simming. :)
