I view them as suggestions and may or may not accept them based on the sim and my mood. I may accept pretty "inconsistent" suggestions just because I find them funny/interesting. Like, I was playing as my actor sim and suddenly the game gave me a popup that Judith Ward dislikes acting. I was like "ok lol, partly explains why she's so grumpy all the time but she still keeps doing it just for the money".
In my Homeless challenge I made it a rule that I HAD to accept every single like/dislike popup. Got lucky with fishing, the sim otherwise ended up disliking almost every single other activity she could do.