Playing The Sims 4 Gives Me Anxiety Now

I understand your dilemma. I have depression and there are things I avoid so I don't trigger a bigger episode than I may have anyway. (I take meds that help a great deal, but there are still things I feel the need to avoid.) In the end you are the best judge of what you need for your health. The idea of a mod would be a good one, if it exists. The other thing I can think of is to play adults that are not likely to get the pop-up. Stop aging or set it to long lifespan and you can play the adult life stage long enough for it to be both YA and adult. It may not be your normal method of play, but it would allow you to play without the anxiety.