I dunno about big saves, but I've got some long lived ones.
The initial vampire save I did that was long term turned into one where the initial vampire served to sire the second which I then decided was my favorite and is 520some days old. I also have a variation of that save where she is stand alone and racking up quite the fortune as the night time shift crime leader... Oracle.
But that first save was unique in that the family won the lotto of a million simoleans and such.. Its getting fairly empty, that first save. That save, vampire retired from Oracle and went to scientists career, then dabbled in stuff... And had children as well, I dont really know how many, just that its been over 10 kids that have been grown up and moved/died/etc..
Similar with the second variable on that save, she's had a number of kids and they've grown and such...
Then there's my Yopson save. He started out in the detective career and had a cat. I eventually let the cat die or something as I started basically seeing how many kids I could get before it broke the game... Thus far, he has fathered 114 kids in total; about 5-10 have already died, and he has several grandkids somewhere in that game. I have taken the choice to export several of his offspring into my library. As far as I can tell, he's had 14 kids with an imported version of Lilith Pleasant and 2-6 children with many of the other females in that game. Even ended a couple papparazi this way.... Nosy things.
Depending on the update, I'm leaning toward Yopson settling down with Lilith Pleasant, maybe 130 kids isnt all that far off anymore...