I haven't really played with either yet (cause I always forget to) but at the moment I prefer Aliens. Vampires are just too...stalkerish to me. Like, every time I play a household, whether in a new save or just switching between families, almost every night without fail there is one standing outside the front door. They just walk up and stand there for a few hours and then leave but it's still annoying cause I have to keep an eye on them (plus how ever many Sims are in the current household) to make sure they don't bite/turn one of my Sims while I'm tending to something else.
Maybe after I actually play with Vampires I'll get a new appreciation for them but until then I'm totally Team Alien!