What is the worst thing that ever happened to your sims?

Aside from problems inflicted by acknowledged game bugs, I once had a sim die of multiple lightning strikes while living in a haunted house. The house became very spectrally active during a thunderstorm, and had him running repeatedly in an out of his home in a state of sheer terror, until the third lightning strike killed him. It probably didn't help that he was afflicted by the Night Wraith curse at the time, and the presence of Temperance certainly didn't make matters any more bearable.